Cathepsin K: boon or bale for atherosclerotic plaque stability?
نویسندگان
چکیده
منابع مشابه
Cathepsin K: boon or bale for atherosclerotic plaque stability?
Cathepsins, cysteine proteases of lysosomes and endosomes, play major physiological roles in general intracellular protein turnover. When they are directed outside the cell, these enzymes also take part in remodelling the extracellular matrix of bone and other tissues. Once in the extracellular matrix, the cathepsins degrade elastin and collagen. Since remodelling of the extracellular matrix of...
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Investigating the determinants and dynamics of atherosclerotic plaque instability is a key area of current cardiovascular research. Extracellular matrix degradation from excessive proteolysis induced by enzymes such as cathepsin K (Cat K) is implicated in the pathogenesis of unstable plaques. The current study assessed the expression of Cat K in human unstable atherosclerotic plaques. Specimens...
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[This corrects the article DOI: 10.3892/etm.2017.4935.].
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It is generally established that the unstable plaque is the major cause of acute clinical sequelae of atherosclerosis. Unfortunately, terms indicating lesions prone to plaque instability, such as "vulnerable plaque," and the different phenotypes of unstable plaques, such as plaque rupture, plaque fissuring, intraplaque hemorrhage, and erosion, are often used interchangeably. Moreover, the diffe...
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Fibronectin is a crucial extracellular matrix (ECM) protein regulating ECM-dependent cell adhesion, migration, and differentiation. Besides being deposited as insoluble fibrils in tissues, it is also produced as soluble dimers by the liver and released in plasma. The presence of fibronectin in atherosclerotic plaques was described more than 20 years ago and plasma fibronectin has been shown to ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2008
ISSN: 0008-6363
DOI: 10.1093/cvr/cvn343